Bile acid signaling at the gut–vascular interface: a novel modulator of hantavirus endothelial barrier dysfunction
B1 Crossref Works API · 2026-07-22 · PUUV
Hantavirus infection triggers life-threatening hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), driven by severe endothelial barrier breakdown and systemic capillary leakage. Clinical severity varies widely with undefined host regulators, and no targeted endothelial-protective treatments exist. Recent data link hantaviruses to gut microbiome remodeling, while bile acid (BA) receptors FXR and TGR5 potently inhibit NF-κB-mediated endothelial inflammation. We synthesize four core lines of evidence. First, metagenomic reports confirm hantavirus reshapes
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HORIZON metadata
| Source | Crossref Works API (crossref) |
|---|---|
| NATO rating | B1 — see methodology |
| Serotype | PUUV |
| Reported date | 2026-07-22 |
| Ingested at | 2026-07-22 12:50 UTC |